GBP2
Gene Information
- Official Symbol: GBP2
- Official Name: guanylate binding protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2634
- UniProt: P32456
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013].
- UniProt Summary: Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). {ECO:0000250|UniProtKB:P32455, ECO:0000269|PubMed:8706832}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15736
- Expression level (log2 read counts): 0.93
GBP2 Expression in NALM6 Cells: 0.93
