GFRAL
Gene Information
- Official Symbol: GFRAL
- Official Name: GDNF family receptor alpha like
- Aliases and Previous Symbols: N/A
- Entrez ID: 389400
- UniProt: Q6UXV0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| GDNF |
GO Terms
| glial cell-derived neurotrophic factor receptor activity |
| reduction of food intake in response to dietary excess |
| glial cell-derived neurotrophic factor receptor signaling pathway |
| response to dietary excess |
| eating behavior |
| negative regulation of signal transduction in absence of ligand |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| receptor tyrosine kinase binding |
| feeding behavior |
| negative regulation of extrinsic apoptotic signaling pathway |
| stress-activated protein kinase signaling cascade |
| negative regulation of neuron apoptotic process |
| regulation of extrinsic apoptotic signaling pathway |
| activation of MAPK activity |
| positive regulation of protein kinase B signaling |
| receptor complex |
| negative regulation of neuron death |
| regulation of neuron apoptotic process |
| regulation of protein kinase B signaling |
| negative regulation of apoptotic signaling pathway |
| positive regulation of MAP kinase activity |
| regulation of neuron death |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| external side of plasma membrane |
| regulation of apoptotic signaling pathway |
| response to nutrient levels |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of protein serine/threonine kinase activity |
| response to extracellular stimulus |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| behavior |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| enzyme linked receptor protein signaling pathway |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of transferase activity |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BML-284 0.09μM R08 exp460 | -1.71 |
| RK-33 8μM R08 exp518 | 2.07 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10327
- Expression level (log2 read counts): 1.37
Expression Distribution
GFRAL Expression in NALM6 Cells: 1.37
