GMEB2

Entrez Summary: N/A
UniProt Summary: Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.32
BI-6727 0.0125μM R03 exp97	1.71
Apcin 25μM plus proTAME 2μM R04 exp177	1.72
GSK343 3μM R03 exp124	1.74
Calcium Ionophore 0.4μM R07 exp342	1.77
Dimethyloxaloylglycine 11μM R07 exp314	1.77
CR131-b 0.005μM R08 exp474	1.84
Radicicol 0.16μM R05 exp242	2
Demecolcine 0.03μM R05 exp228	2.08

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution