GPN3

Entrez Summary: N/A
UniProt Summary: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. {ECO:0000269|PubMed:21768307}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Quinacrine 2.5μM R03 exp146	-2.04

Global Fraction of Cell Lines Where Essential: 711/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	26/28
bone	23/26
breast	33/33
central nervous system	54/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	20/21
liver	19/20
lung	72/75
lymphocyte	15/16
ovary	26/26
pancreas	23/24
peripheral nervous system	14/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	28/29
uterus	4/5

Expression Distribution