GPR126
Gene Information
- Official Symbol: ADGRG6
- Official Name: adhesion G protein-coupled receptor G6
- Aliases and Previous Symbols: N/A
- Entrez ID: 57211
- UniProt: Q86SQ4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009].
- UniProt Summary: G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity). {ECO:0000250|UniProtKB:C6KFA3, ECO:0000269|PubMed:24227709, ECO:0000269|PubMed:26004201}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16479
- Expression level (log2 read counts): -6.02
GPR126 Expression in NALM6 Cells: -6.02
