GTPBP4
Gene Information
- Official Symbol: GTPBP4
- Official Name: GTP binding protein 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 23560
- UniProt: Q9BZE4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the biogenesis of the 60S ribosomal subunit. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| NOGCT |
| Miro |
| FeoB N |
| MMR HSR1 |
| NOG1 |
GO Terms
| negative regulation of collagen binding |
| regulation of collagen binding |
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| maturation of LSU-rRNA |
| negative regulation of DNA replication |
| ribosomal large subunit biogenesis |
| negative regulation of protein ubiquitination |
| negative regulation of protein modification by small protein conjugation or removal |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of cyclin-dependent protein kinase activity |
| regulation of DNA replication |
| osteoblast differentiation |
| negative regulation of binding |
| negative regulation of cell-cell adhesion |
| protein stabilization |
| regulation of protein ubiquitination |
| rRNA processing |
| rRNA metabolic process |
| regulation of protein modification by small protein conjugation or removal |
| nuclear membrane |
| negative regulation of cell migration |
| ossification |
| negative regulation of cell adhesion |
| negative regulation of cell motility |
| regulation of protein stability |
| ribosome biogenesis |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| GTPase activity |
| regulation of binding |
| ncRNA processing |
| GTP binding |
| regulation of cell-cell adhesion |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| regulation of protein serine/threonine kinase activity |
| negative regulation of protein modification process |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| perinuclear region of cytoplasm |
| regulation of protein kinase activity |
| regulation of cell migration |
| nucleolus |
| regulation of kinase activity |
| RNA processing |
| regulation of cell motility |
| regulation of transferase activity |
| regulation of locomotion |
| Golgi apparatus |
| regulation of cellular component movement |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| RNA metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 684/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 25/28 |
| blood | 25/28 |
| bone | 25/26 |
| breast | 28/33 |
| central nervous system | 52/56 |
| cervix | 4/4 |
| colorectal | 14/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 19/21 |
| liver | 19/20 |
| lung | 70/75 |
| lymphocyte | 14/16 |
| ovary | 24/26 |
| pancreas | 23/24 |
| peripheral nervous system | 14/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 19/22 |
| urinary tract | 26/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 627
- Expression level (log2 read counts): 7.43
Expression Distribution
GTPBP4 Expression in NALM6 Cells: 7.43
