HCLS1
Gene Information
- Official Symbol: HCLS1
- Official Name: hematopoietic cell-specific Lyn substrate 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3059
- UniProt: P14317
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Pfam Domains GO Terms
Pfam Domains
| SH3 1 |
| SH3 2 |
| HS1 rep |
GO Terms
| site of polarized growth |
| positive regulation of granulocyte differentiation |
| positive regulation of macrophage differentiation |
| regulation of granulocyte differentiation |
| positive regulation of actin cytoskeleton reorganization |
| regulation of macrophage differentiation |
| actin filament polymerization |
| regulation of actin cytoskeleton reorganization |
| positive regulation of protein import into nucleus |
| positive regulation of protein import |
| negative regulation of leukocyte apoptotic process |
| actin polymerization or depolymerization |
| cortical actin cytoskeleton |
| regulation of protein import into nucleus |
| positive regulation of myeloid leukocyte differentiation |
| regulation of protein import |
| RNA polymerase II transcription factor binding |
| positive regulation of nucleocytoplasmic transport |
| positive regulation of tyrosine phosphorylation of STAT protein |
| positive regulation of protein localization to nucleus |
| regulation of tyrosine phosphorylation of STAT protein |
| erythrocyte differentiation |
| actin filament |
| regulation of leukocyte apoptotic process |
| positive regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| protein polymerization |
| positive regulation of receptor signaling pathway via STAT |
| erythrocyte homeostasis |
| positive regulation of myeloid cell differentiation |
| positive regulation of peptidyl-serine phosphorylation |
| regulation of nucleocytoplasmic transport |
| myeloid cell homeostasis |
| regulation of myeloid leukocyte differentiation |
| regulation of protein localization to nucleus |
| regulation of phosphatidylinositol 3-kinase signaling |
| regulation of receptor signaling pathway via JAK-STAT |
| SH3 domain binding |
| regulation of receptor signaling pathway via STAT |
| regulation of peptidyl-serine phosphorylation |
| positive regulation of leukocyte differentiation |
| positive regulation of intracellular protein transport |
| positive regulation of protein kinase B signaling |
| regulation of actin filament polymerization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of hemopoiesis |
| positive regulation of peptidyl-tyrosine phosphorylation |
| homeostasis of number of cells |
| actin filament binding |
| transcription factor complex |
| positive regulation of intracellular transport |
| regulation of protein kinase B signaling |
| positive regulation of cytoskeleton organization |
| myeloid cell differentiation |
| regulation of protein polymerization |
| regulation of myeloid cell differentiation |
| regulation of intracellular protein transport |
| actin filament organization |
| regulation of peptidyl-tyrosine phosphorylation |
| regulation of actin filament organization |
| positive regulation of DNA-binding transcription factor activity |
| protein-containing complex binding |
| actin binding |
| regulation of leukocyte differentiation |
| positive regulation of cellular protein localization |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| regulation of intracellular transport |
| regulation of cellular component size |
| regulation of actin filament-based process |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| regulation of hemopoiesis |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| actin cytoskeleton organization |
| regulation of anatomical structure size |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| hemopoiesis |
| actin filament-based process |
| hematopoietic or lymphoid organ development |
| positive regulation of organelle organization |
| immune system development |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| cellular protein-containing complex assembly |
| negative regulation of transcription by RNA polymerase II |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| positive regulation of transport |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| response to cytokine |
| cytoskeleton organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| mitochondrion |
| regulation of organelle organization |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| XYLT2 | 0.404 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2564
- Expression level (log2 read counts): 5.64
Expression Distribution
HCLS1 Expression in NALM6 Cells: 5.64
