HOXB4
Gene Information
- Official Symbol: HOXB4
- Official Name: homeobox B4
- Aliases and Previous Symbols: N/A
- Entrez ID: 3214
- UniProt: P17483
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
GO Terms
| bone marrow development |
| hematopoietic stem cell differentiation |
| definitive hemopoiesis |
| positive regulation of stem cell differentiation |
| somatic stem cell division |
| spleen development |
| activating transcription factor binding |
| stem cell division |
| morphogenesis of an epithelial sheet |
| hematopoietic progenitor cell differentiation |
| embryonic skeletal system morphogenesis |
| regulation of stem cell differentiation |
| embryonic skeletal system development |
| stem cell differentiation |
| bone development |
| anterior/posterior pattern specification |
| skeletal system morphogenesis |
| embryonic organ morphogenesis |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regionalization |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| centrosome |
| cell division |
| skeletal system development |
| cell population proliferation |
| hemopoiesis |
| tissue morphogenesis |
| embryonic morphogenesis |
| hematopoietic or lymphoid organ development |
| chordate embryonic development |
| immune system development |
| embryo development ending in birth or egg hatching |
| negative regulation of transcription by RNA polymerase II |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| IU1-C 25μM R04 exp183 | -2.11 |
| Temozolomide 200μM R04 exp189 | -1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14157
- Expression level (log2 read counts): -1.4
Expression Distribution
HOXB4 Expression in NALM6 Cells: -1.4
