HOXD3
Gene Information
- Official Symbol: HOXD3
- Official Name: homeobox D3
- Aliases and Previous Symbols: N/A
- Entrez ID: 3232
- UniProt: P31249
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
GO Terms
| glossopharyngeal nerve morphogenesis |
| glossopharyngeal nerve development |
| thyroid gland development |
| cranial nerve morphogenesis |
| aggresome |
| cranial nerve development |
| nerve development |
| embryonic skeletal system morphogenesis |
| endocrine system development |
| Notch signaling pathway |
| cell-matrix adhesion |
| embryonic skeletal system development |
| cartilage development |
| cell-substrate adhesion |
| anterior/posterior pattern specification |
| connective tissue development |
| skeletal system morphogenesis |
| nuclear body |
| embryonic organ morphogenesis |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regionalization |
| positive regulation of neuron differentiation |
| gland development |
| embryonic organ development |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| positive regulation of neurogenesis |
| skeletal system development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| positive regulation of nervous system development |
| positive regulation of cell development |
| embryonic morphogenesis |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| regulation of neuron differentiation |
| DNA-binding transcription factor activity |
| regulation of neurogenesis |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| organic cyclic compound biosynthetic process |
| positive regulation of developmental process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18445
- Expression level (log2 read counts): -6.6
Expression Distribution
HOXD3 Expression in NALM6 Cells: -6.6
