Pfam Domains GO Terms
| HSP70 |
| MreB Mbl |
| endoplasmic reticulum chaperone complex |
| ATPase activity, coupled |
| protein folding chaperone |
| misfolded protein binding |
| chaperone cofactor-dependent protein refolding |
| protein refolding |
| de novo posttranslational protein folding |
| de novo protein folding |
| chaperone-mediated protein folding |
| heat shock protein binding |
| cellular response to heat |
| ubiquitin-dependent ERAD pathway |
| ERAD pathway |
| endoplasmic reticulum unfolded protein response |
| response to heat |
| cellular response to unfolded protein |
| unfolded protein binding |
| cellular response to topologically incorrect protein |
| response to unfolded protein |
| response to temperature stimulus |
| response to topologically incorrect protein |
| protein folding |
| ATPase activity |
| response to endoplasmic reticulum stress |
| endoplasmic reticulum lumen |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| protein catabolic process |
| intracellular membrane-bounded organelle |
| cellular macromolecule catabolic process |
| response to organonitrogen compound |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| response to abiotic stimulus |
| proteolysis |
| ATP binding |
| cellular response to stress |
| organic substance catabolic process |
| cellular catabolic process |
| membrane |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution