ITGA1
Gene Information
- Official Symbol: ITGA1
- Official Name: integrin subunit alpha 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3672
- UniProt: P56199
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. {ECO:0000269|PubMed:15592458}.
Pfam Domains GO Terms
Pfam Domains
| FG-GAP |
| VWA |
| Integrin alpha2 |
GO Terms
| integrin alpha1-beta1 complex |
| collagen binding involved in cell-matrix adhesion |
| basal part of cell |
| positive regulation of phosphoprotein phosphatase activity |
| integrin complex |
| vasodilation |
| positive regulation of phosphatase activity |
| cellular extravasation |
| positive regulation of protein dephosphorylation |
| negative regulation of epidermal growth factor receptor signaling pathway |
| negative regulation of ERBB signaling pathway |
| positive regulation of neuron apoptotic process |
| positive regulation of blood vessel diameter |
| positive regulation of dephosphorylation |
| collagen binding |
| neutrophil chemotaxis |
| regulation of epidermal growth factor receptor signaling pathway |
| protein phosphatase binding |
| acrosomal vesicle |
| granulocyte chemotaxis |
| regulation of ERBB signaling pathway |
| neutrophil migration |
| positive regulation of neuron death |
| integrin-mediated signaling pathway |
| granulocyte migration |
| regulation of phosphoprotein phosphatase activity |
| cell-matrix adhesion |
| myeloid leukocyte migration |
| perikaryon |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of protein dephosphorylation |
| regulation of tube size |
| leukocyte chemotaxis |
| activation of MAPK activity |
| vascular process in circulatory system |
| regulation of phosphatase activity |
| cell-substrate adhesion |
| regulation of neuron apoptotic process |
| cell chemotaxis |
| regulation of dephosphorylation |
| membrane raft |
| muscle contraction |
| positive regulation of MAP kinase activity |
| muscle system process |
| regulation of neuron death |
| neuron projection |
| activation of protein kinase activity |
| signaling receptor binding |
| positive regulation of protein serine/threonine kinase activity |
| extracellular matrix organization |
| regulation of MAP kinase activity |
| leukocyte migration |
| extracellular structure organization |
| blood circulation |
| external side of plasma membrane |
| circulatory system process |
| focal adhesion |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell part morphogenesis |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| positive regulation of kinase activity |
| cell surface |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| neuron projection development |
| negative regulation of cell population proliferation |
| positive regulation of cell death |
| cell morphogenesis |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| regulation of protein kinase activity |
| neuron development |
| cellular component morphogenesis |
| regulation of kinase activity |
| cell adhesion |
| biological adhesion |
| cell migration |
| regulation of transferase activity |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| cell motility |
| localization of cell |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| cell projection organization |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Quinacrine 2.5μM R03 exp146 | 1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7003
- Expression level (log2 read counts): 2.9
Expression Distribution
ITGA1 Expression in NALM6 Cells: 2.9
