IVNS1ABP

• Official Symbol: IVNS1ABP
• Official Name: influenza virus NS1A binding protein
• Aliases and Previous Symbols: N/A
• Entrez ID: 10625
• UniProt: Q9Y6Y0
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: N/A
• UniProt Summary: Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. {ECO:0000250, ECO:0000269|PubMed:16582008}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 19082
• Expression level (log2 read counts): 7.65

Expression Distribution

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IVNS1ABP Expression in NALM6 Cells: 7.65