KCNU1
Gene Information
- Official Symbol: KCNU1
- Official Name: potassium calcium-activated channel subfamily U member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 157855
- UniProt: A8MYU2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. {ECO:0000269|PubMed:23129643}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12308
- Expression level (log2 read counts): -7.68
KCNU1 Expression in NALM6 Cells: -7.68
