KIR2DL4
Gene Information
- Official Symbol: KIR2DL4
- Official Name: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 3805
- UniProt: Q99706
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| ig |
GO Terms
| MHC class Ib receptor activity |
| positive regulation of natural killer cell cytokine production |
| regulation of natural killer cell cytokine production |
| positive regulation of cellular senescence |
| negative regulation of natural killer cell mediated cytotoxicity |
| positive regulation of cell aging |
| negative regulation of natural killer cell mediated immunity |
| negative regulation of leukocyte mediated cytotoxicity |
| negative regulation of cell killing |
| positive regulation of natural killer cell mediated immunity |
| negative regulation of lymphocyte mediated immunity |
| regulation of cellular senescence |
| regulation of natural killer cell mediated cytotoxicity |
| regulation of natural killer cell mediated immunity |
| regulation of cell aging |
| negative regulation of leukocyte mediated immunity |
| cellular defense response |
| positive regulation of cytokine production involved in immune response |
| negative regulation of innate immune response |
| regulation of leukocyte mediated cytotoxicity |
| regulation of cytokine production involved in immune response |
| negative regulation of response to biotic stimulus |
| positive regulation of production of molecular mediator of immune response |
| regulation of cell killing |
| positive regulation of lymphocyte mediated immunity |
| negative regulation of immune effector process |
| positive regulation of leukocyte mediated immunity |
| transmembrane signaling receptor activity |
| regulation of production of molecular mediator of immune response |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| early endosome membrane |
| regulation of leukocyte mediated immunity |
| negative regulation of defense response |
| negative regulation of multi-organism process |
| positive regulation of immune effector process |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| negative regulation of response to external stimulus |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| positive regulation of response to external stimulus |
| regulation of cytokine production |
| regulation of cellular response to stress |
| regulation of defense response |
| regulation of multi-organism process |
| positive regulation of immune response |
| regulation of response to external stimulus |
| positive regulation of immune system process |
| regulation of immune response |
| defense response |
| positive regulation of developmental process |
| integral component of plasma membrane |
| regulation of response to stress |
| negative regulation of response to stimulus |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14044
- Expression level (log2 read counts): 3.55
Expression Distribution
KIR2DL4 Expression in NALM6 Cells: 3.55
