LILRB2
Gene Information
- Official Symbol: LILRB2
- Official Name: leukocyte immunoglobulin like receptor B2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10288
- UniProt: Q8N423
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:12853576, ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| negative regulation of postsynaptic density organization |
| inhibitory MHC class I receptor activity |
| MHC class Ib protein complex binding |
| Fc receptor mediated inhibitory signaling pathway |
| MHC class Ib protein binding |
| positive regulation of T cell tolerance induction |
| immune response-inhibiting cell surface receptor signaling pathway |
| positive regulation of long-term synaptic depression |
| immune response-inhibiting signal transduction |
| regulation of T cell tolerance induction |
| negative regulation of antigen processing and presentation |
| positive regulation of tolerance induction |
| regulation of dendritic cell differentiation |
| positive regulation of regulatory T cell differentiation |
| regulation of long-term synaptic depression |
| regulation of postsynaptic density organization |
| regulation of tolerance induction |
| MHC class I protein binding |
| protein phosphatase 1 binding |
| regulation of antigen processing and presentation |
| negative regulation of synapse organization |
| regulation of regulatory T cell differentiation |
| heterotypic cell-cell adhesion |
| positive regulation of protein dephosphorylation |
| regulation of long-term synaptic potentiation |
| cellular defense response |
| cell adhesion molecule binding |
| positive regulation of dephosphorylation |
| negative regulation of T cell proliferation |
| negative regulation of calcium ion transport |
| ficolin-1-rich granule membrane |
| tertiary granule membrane |
| negative regulation of lymphocyte proliferation |
| negative regulation of mononuclear cell proliferation |
| negative regulation of leukocyte proliferation |
| amyloid-beta binding |
| positive regulation of T cell differentiation |
| positive regulation of lymphocyte differentiation |
| positive regulation of interleukin-6 production |
| positive regulation of T cell proliferation |
| regulation of postsynapse organization |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte proliferation |
| regulation of T cell differentiation |
| regulation of interleukin-6 production |
| regulation of protein dephosphorylation |
| negative regulation of lymphocyte activation |
| positive regulation of leukocyte differentiation |
| negative regulation of ion transport |
| regulation of T cell proliferation |
| regulation of lymphocyte differentiation |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| cellular response to lipopolysaccharide |
| positive regulation of hemopoiesis |
| regulation of synaptic plasticity |
| cellular response to molecule of bacterial origin |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of dephosphorylation |
| cellular response to biotic stimulus |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of synapse organization |
| regulation of leukocyte proliferation |
| regulation of synapse structure or activity |
| regulation of calcium ion transport |
| positive regulation of cell-cell adhesion |
| learning or memory |
| protein-containing complex binding |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| regulation of leukocyte cell-cell adhesion |
| cognition |
| response to lipopolysaccharide |
| regulation of T cell activation |
| response to molecule of bacterial origin |
| positive regulation of lymphocyte activation |
| negative regulation of organelle organization |
| regulation of metal ion transport |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| modulation of chemical synaptic transmission |
| negative regulation of immune system process |
| regulation of trans-synaptic signaling |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| immune response-regulating cell surface receptor signaling pathway |
| negative regulation of transport |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| cell-cell adhesion |
| leukocyte degranulation |
| regulation of lymphocyte activation |
| myeloid leukocyte mediated immunity |
| cellular response to lipid |
| myeloid cell activation involved in immune response |
| behavior |
| myeloid leukocyte activation |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| adaptive immune response |
| cell surface |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| regulation of ion transport |
| regulated exocytosis |
| negative regulation of cellular component organization |
| leukocyte mediated immunity |
| exocytosis |
| response to lipid |
| protein homodimerization activity |
| positive regulation of cell population proliferation |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| positive regulation of cell differentiation |
| secretion by cell |
| export from cell |
| cellular response to oxygen-containing compound |
| cell activation |
| immune effector process |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of protein modification process |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| nervous system process |
| integral component of plasma membrane |
| response to oxygen-containing compound |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cannabidiol 20μM R08 exp466 | -2.01 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.465 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8678
- Expression level (log2 read counts): 2.03
Expression Distribution
LILRB2 Expression in NALM6 Cells: 2.03
