LMTK3
Gene Information
- Official Symbol: LMTK3
- Official Name: lemur tyrosine kinase 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 114783
- UniProt: Q96Q04
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity). {ECO:0000250|UniProtKB:Q5XJV6, ECO:0000269|PubMed:21602804}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6567
- Expression level (log2 read counts): -0.78
LMTK3 Expression in NALM6 Cells: -0.78
