LRIT3
Gene Information
- Official Symbol: LRIT3
- Official Name: leucine rich repeat, Ig-like and transmembrane domains 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 345193
- UniProt: Q3SXY7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that has a fibronectin type III domain and a C-terminal transmembrane domain, as well as a leucine-rich repeat domain and immunoglobulin-like domain near the N-terminus. The encoded protein may regulate fibroblast growth factor receptors and affect the modification of these receptors, which are glycosylated differently in the Golgi and endoplasmic reticulum. Mutations in this gene are associated with congenital stationary night blindness, type 1F. [provided by RefSeq, May 2013].
- UniProt Summary: Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (By similarity). May also have a role in cone synapse formation (By similarity). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (PubMed:22673519). Could be a regulator of the FGFRs (PubMed:22673519). {ECO:0000250|UniProtKB:W8DXL4, ECO:0000269|PubMed:22673519}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13607
- Expression level (log2 read counts): -0.19
LRIT3 Expression in NALM6 Cells: -0.19
