MAVS
Gene Information
- Official Symbol: MAVS
- Official Name: mitochondrial antiviral signaling protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 57506
- UniProt: Q7Z434
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| regulation of IP-10 production |
| positive regulation of IP-10 production |
| regulation of peroxisome organization |
| positive regulation of interferon-beta secretion |
| regulation of interferon-beta secretion |
| positive regulation of chemokine (C-C motif) ligand 5 production |
| regulation of myeloid dendritic cell cytokine production |
| positive regulation of myeloid dendritic cell cytokine production |
| positive regulation of dendritic cell cytokine production |
| regulation of chemokine (C-C motif) ligand 5 production |
| regulation of interferon-alpha secretion |
| positive regulation of interferon-alpha secretion |
| regulation of dendritic cell cytokine production |
| signaling adaptor activity |
| positive regulation of type I interferon-mediated signaling pathway |
| CARD domain binding |
| cellular response to exogenous dsRNA |
| positive regulation of myeloid leukocyte cytokine production involved in immune response |
| positive regulation of tumor necrosis factor secretion |
| cellular response to dsRNA |
| positive regulation of interferon-alpha production |
| positive regulation of defense response to virus by host |
| regulation of tumor necrosis factor secretion |
| regulation of interferon-alpha production |
| positive regulation of interferon-beta production |
| positive regulation of myeloid leukocyte mediated immunity |
| positive regulation of interleukin-6 secretion |
| regulation of type I interferon-mediated signaling pathway |
| positive regulation of protein import into nucleus |
| regulation of defense response to virus by host |
| positive regulation of protein import |
| negative regulation of type I interferon production |
| response to exogenous dsRNA |
| regulation of interferon-beta production |
| positive regulation of interleukin-8 production |
| positive regulation of cytokine-mediated signaling pathway |
| response to dsRNA |
| positive regulation of cytokine production involved in immune response |
| regulation of protein import into nucleus |
| positive regulation of chemokine production |
| negative regulation of viral genome replication |
| positive regulation of response to cytokine stimulus |
| peroxisomal membrane |
| regulation of myeloid leukocyte mediated immunity |
| regulation of protein import |
| positive regulation of nucleocytoplasmic transport |
| regulation of interleukin-8 production |
| regulation of defense response to virus |
| positive regulation of protein localization to nucleus |
| regulation of chemokine production |
| positive regulation of type I interferon production |
| negative regulation of viral life cycle |
| regulation of cytokine production involved in immune response |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| regulation of viral genome replication |
| positive regulation of interleukin-6 production |
| positive regulation of production of molecular mediator of immune response |
| negative regulation of viral process |
| mitochondrial membrane |
| regulation of nucleocytoplasmic transport |
| regulation of protein localization to nucleus |
| regulation of type I interferon production |
| positive regulation of leukocyte mediated immunity |
| positive regulation of cytokine secretion |
| regulation of interleukin-6 production |
| regulation of production of molecular mediator of immune response |
| regulation of viral life cycle |
| regulation of tumor necrosis factor production |
| regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of intracellular protein transport |
| mitochondrial outer membrane |
| regulation of cytokine-mediated signaling pathway |
| regulation of response to cytokine stimulus |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| defense response to virus |
| regulation of cytokine secretion |
| regulation of viral process |
| regulation of leukocyte mediated immunity |
| positive regulation of intracellular transport |
| negative regulation of multi-organism process |
| positive regulation of immune effector process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of intracellular protein transport |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| activation of innate immune response |
| positive regulation of DNA-binding transcription factor activity |
| positive regulation of protein secretion |
| negative regulation of cytokine production |
| response to virus |
| positive regulation of peptide secretion |
| positive regulation of cellular protein localization |
| defense response to bacterium |
| positive regulation of innate immune response |
| regulation of intracellular transport |
| positive regulation of response to biotic stimulus |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| positive regulation of secretion |
| positive regulation of cytokine production |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| regulation of protein secretion |
| regulation of immune effector process |
| positive regulation of defense response |
| regulation of peptide secretion |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| regulation of cellular protein localization |
| cellular response to organic cyclic compound |
| positive regulation of response to external stimulus |
| activation of immune response |
| cellular response to nitrogen compound |
| response to bacterium |
| regulation of cytokine production |
| viral process |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| symbiotic process |
| regulation of secretion |
| interspecies interaction between organisms |
| positive regulation of immune response |
| regulation of cellular localization |
| response to organic cyclic compound |
| defense response to other organism |
| positive regulation of transport |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| immune effector process |
| regulation of response to external stimulus |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| mitochondrion |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| regulation of protein phosphorylation |
| regulation of response to stress |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Daidzin 10μM R06 exp280 | 1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4584
- Expression level (log2 read counts): 7.65
Expression Distribution
MAVS Expression in NALM6 Cells: 7.65
