MC2R
Gene Information
- Official Symbol: MC2R
- Official Name: melanocortin 2 receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 4158
- UniProt: Q01718
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014].
- UniProt Summary: Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). {ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17939
- Expression level (log2 read counts): 3.15
MC2R Expression in NALM6 Cells: 3.15
