Pfam Domains GO Terms
| malic |
| Malic M |
| malate dehydrogenase (decarboxylating) (NAD+) activity |
| malate dehydrogenase (decarboxylating) (NADP+) activity |
| regulation of NADP metabolic process |
| oxaloacetate decarboxylase activity |
| malic enzyme activity |
| malate metabolic process |
| NADP binding |
| ADP binding |
| NAD binding |
| manganese ion binding |
| pyruvate metabolic process |
| electron transfer activity |
| dicarboxylic acid metabolic process |
| protein tetramerization |
| response to carbohydrate |
| electron transport chain |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| regulation of lipid metabolic process |
| generation of precursor metabolites and energy |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| carbohydrate metabolic process |
| protein complex oligomerization |
| monocarboxylic acid metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| response to hormone |
| oxidation-reduction process |
| oxoacid metabolic process |
| organic acid metabolic process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| mitochondrion |
| organic cyclic compound biosynthetic process |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| protein-containing complex subunit organization |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| CAY10603 0.55μM R08 exp467 | 1.76 |
| BI-6727 0.0125μM R03 exp97 | 2.29 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution