MIS12

Entrez Summary: N/A
UniProt Summary: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108). {ECO:0000269|PubMed:12515822, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270, ECO:0000269|PubMed:23891108}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Benzoate 20000μM R08 exp456	-1.79

Global Fraction of Cell Lines Where Essential: 127/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	3/28
blood	5/28
bone	8/26
breast	7/33
central nervous system	8/56
cervix	1/4
colorectal	4/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	3/21
liver	4/20
lung	12/75
lymphocyte	3/16
ovary	4/26
pancreas	6/24
peripheral nervous system	8/16
plasma cell	2/15
prostate	1/1
skin	0/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	7/29
uterus	1/5

Expression Distribution