NABP1
Gene Information
- Official Symbol: N/ABP1
- Official Name: nucleic acid binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 64859
- UniProt: Q96AH0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17017
- Expression level (log2 read counts): 5.84
NABP1 Expression in NALM6 Cells: 5.84
