NEK8
Gene Information
- Official Symbol: NEK8
- Official Name: NIMA related kinase 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 284086
- UniProt: Q86SG6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008].
- UniProt Summary: Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. {ECO:0000250, ECO:0000269|PubMed:23418306}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13259
- Expression level (log2 read counts): 4.27
NEK8 Expression in NALM6 Cells: 4.27
