NME5

Gene Information

Official Symbol: NME5
Official Name: NME/NM23 family member 5
Aliases and Previous Symbols: N/A
Entrez ID: 8382
UniProt: P56597
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Pfam Domains

NDK

Dpy-30

GO Terms

UTP biosynthetic process

GTP biosynthetic process

UTP metabolic process

CTP metabolic process

guanosine-containing compound biosynthetic process

CTP biosynthetic process

pyrimidine ribonucleoside triphosphate biosynthetic process

pyrimidine ribonucleoside triphosphate metabolic process

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

pyrimidine nucleoside triphosphate biosynthetic process

nucleoside diphosphate kinase activity

pyrimidine ribonucleotide biosynthetic process

ribonucleoside biosynthetic process

purine ribonucleoside biosynthetic process

pyrimidine nucleoside triphosphate metabolic process

purine nucleoside biosynthetic process

pyrimidine ribonucleotide metabolic process

GTP metabolic process

ventricular system development

epithelial cilium movement involved in extracellular fluid movement

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

extracellular transport

nucleoside biosynthetic process

guanosine-containing compound metabolic process

glycosyl compound biosynthetic process

sperm flagellum

negative regulation of oxidative stress-induced cell death

purine ribonucleoside triphosphate biosynthetic process

negative regulation of cellular response to oxidative stress

purine nucleoside triphosphate biosynthetic process

pyrimidine nucleotide biosynthetic process

negative regulation of response to oxidative stress

ribonucleoside triphosphate biosynthetic process

pyrimidine-containing compound biosynthetic process

purine ribonucleoside triphosphate metabolic process

cilium movement

nucleoside diphosphate phosphorylation

purine ribonucleoside metabolic process

nucleotide phosphorylation

pyrimidine nucleotide metabolic process

nucleoside triphosphate biosynthetic process

regulation of oxidative stress-induced cell death

purine nucleoside metabolic process

ribonucleoside triphosphate metabolic process

purine nucleoside triphosphate metabolic process

regulation of cellular response to oxidative stress

ribonucleoside metabolic process

nucleoside diphosphate metabolic process

regulation of response to oxidative stress

nucleoside triphosphate metabolic process

negative regulation of intrinsic apoptotic signaling pathway

pyrimidine-containing compound metabolic process

nucleobase-containing small molecule biosynthetic process

nucleoside metabolic process

glycosyl compound metabolic process

purine ribonucleotide biosynthetic process

spermatid development

purine nucleotide biosynthetic process

spermatid differentiation

regulation of intrinsic apoptotic signaling pathway

ribonucleotide biosynthetic process

ribose phosphate biosynthetic process

purine-containing compound biosynthetic process

microtubule-based transport

negative regulation of apoptotic signaling pathway

nucleotide biosynthetic process

nucleoside phosphate biosynthetic process

germ cell development

microtubule-based movement

purine ribonucleotide metabolic process

ribonucleotide metabolic process

purine nucleotide metabolic process

ribose phosphate metabolic process

cilium assembly

cellular process involved in reproduction in multicellular organism

purine-containing compound metabolic process

cilium organization

regulation of apoptotic signaling pathway

nucleotide metabolic process

plasma membrane bounded cell projection assembly

cellular component

nucleoside phosphate metabolic process

cell projection assembly

negative regulation of intracellular signal transduction

organophosphate biosynthetic process

nucleobase-containing small molecule metabolic process

spermatogenesis

male gamete generation

small molecule biosynthetic process

carbohydrate derivative biosynthetic process

developmental process involved in reproduction

microtubule-based process

gamete generation

regulation of cellular response to stress

brain development

organelle assembly

head development

multicellular organismal reproductive process

sexual reproduction

multicellular organism reproduction

organophosphate metabolic process

negative regulation of apoptotic process

negative regulation of programmed cell death

central nervous system development

negative regulation of cell death

multi-organism reproductive process

carbohydrate derivative metabolic process

nucleobase-containing compound biosynthetic process

plasma membrane bounded cell projection organization

cell projection organization

heterocycle biosynthetic process

aromatic compound biosynthetic process

negative regulation of signal transduction

phosphorylation

organic cyclic compound biosynthetic process

negative regulation of cell communication

negative regulation of signaling

organonitrogen compound biosynthetic process

reproductive process

reproduction

regulation of response to stress

regulation of apoptotic process

movement of cell or subcellular component

regulation of programmed cell death

negative regulation of response to stimulus

cellular nitrogen compound biosynthetic process

cell development

regulation of cell death

small molecule metabolic process

regulation of intracellular signal transduction

extracellular region

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

Screen	Score
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-2.02
2-Deoxy-D-glucose 800μM R05 exp214	1.77

Most Correlated Genes in Chemogenomics

No correlation found to any other genes in chemogenomics.

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16253
Expression level (log2 read counts): -1.72

Expression Distribution