NOX3
Gene Information
- Official Symbol: NOX3
- Official Name: N/ADPH oxidase 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 50508
- UniProt: Q9HBY0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009].
- UniProt Summary: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. {ECO:0000269|PubMed:15824103}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15058
- Expression level (log2 read counts): -7.68
NOX3 Expression in NALM6 Cells: -7.68
