OSR2
Gene Information
- Official Symbol: OSR2
- Official Name: odd-skipped related transciption factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 116039
- UniProt: Q8N2R0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| zf-C2H2 |
GO Terms
| embryonic skeletal limb joint morphogenesis |
| limb joint morphogenesis |
| osteoblast proliferation |
| embryonic skeletal joint morphogenesis |
| eyelid development in camera-type eye |
| embryonic skeletal joint development |
| middle ear morphogenesis |
| embryonic hindlimb morphogenesis |
| embryonic forelimb morphogenesis |
| hindlimb morphogenesis |
| positive regulation of bone mineralization |
| forelimb morphogenesis |
| positive regulation of biomineralization |
| positive regulation of biomineral tissue development |
| embryonic digit morphogenesis |
| regulation of bone mineralization |
| chondrocyte differentiation |
| metanephros development |
| positive regulation of ossification |
| roof of mouth development |
| mesonephros development |
| regulation of biomineral tissue development |
| regulation of biomineralization |
| embryonic skeletal system morphogenesis |
| bone morphogenesis |
| ear morphogenesis |
| odontogenesis |
| embryonic appendage morphogenesis |
| embryonic limb morphogenesis |
| embryonic skeletal system development |
| appendage morphogenesis |
| limb morphogenesis |
| cartilage development |
| limb development |
| appendage development |
| positive regulation of epithelial cell proliferation |
| regulation of ossification |
| bone development |
| ear development |
| connective tissue development |
| skeletal system morphogenesis |
| sensory organ morphogenesis |
| kidney development |
| renal system development |
| embryonic organ morphogenesis |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| camera-type eye development |
| urogenital system development |
| regulation of epithelial cell proliferation |
| eye development |
| visual system development |
| sensory system development |
| sequence-specific DNA binding |
| embryonic organ development |
| skeletal system development |
| sensory organ development |
| cell population proliferation |
| embryonic morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| head development |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of cell population proliferation |
| animal organ morphogenesis |
| embryo development |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nifuroxazide 5μM R03 exp102 | -1.98 |
| Rotenone 2μM R00 exp33 | -1.95 |
| LY2090314 0.003μM R08 exp500 no dilution day6 | -1.7 |
| Caffeine 2600μM R08 exp463 | 1.83 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16739
- Expression level (log2 read counts): 3.33
Expression Distribution
OSR2 Expression in NALM6 Cells: 3.33
