PADI3
Gene Information
- Official Symbol: PADI3
- Official Name: peptidyl arginine deiminase 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 51702
- UniProt: Q9ULW8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008].
- UniProt Summary: Catalyzes the deimination of arginine residues of proteins. {ECO:0000269|PubMed:27866708}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4184
- Expression level (log2 read counts): -5.01
PADI3 Expression in NALM6 Cells: -5.01
