PDCD4
Gene Information
- Official Symbol: PDCD4
- Official Name: programmed cell death 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 27250
- UniProt: Q53EL6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.
Pfam Domains GO Terms
Pfam Domains
| MA3 |
GO Terms
| epithelial to mesenchymal transition involved in cardiac fibroblast development |
| epicardium-derived cardiac fibroblast cell differentiation |
| negative regulation of myofibroblast differentiation |
| cardiac fibroblast cell differentiation |
| cardiac fibroblast cell development |
| epicardium-derived cardiac fibroblast cell development |
| regulation of myofibroblast differentiation |
| positive regulation of vascular associated smooth muscle cell apoptotic process |
| negative regulation of vascular smooth muscle cell differentiation |
| regulation of vascular associated smooth muscle cell apoptotic process |
| negative regulation of JUN kinase activity |
| regulation of vascular smooth muscle cell differentiation |
| positive regulation of smooth muscle cell apoptotic process |
| negative regulation of smooth muscle cell differentiation |
| negative regulation of cytokine production involved in inflammatory response |
| negative regulation of vascular smooth muscle cell proliferation |
| positive regulation of endothelial cell apoptotic process |
| regulation of smooth muscle cell apoptotic process |
| cardiac epithelial to mesenchymal transition |
| positive regulation of muscle cell apoptotic process |
| regulation of smooth muscle cell differentiation |
| positive regulation of epithelial cell apoptotic process |
| negative regulation of JNK cascade |
| regulation of cytokine production involved in inflammatory response |
| negative regulation of stress-activated protein kinase signaling cascade |
| negative regulation of smooth muscle cell proliferation |
| negative regulation of stress-activated MAPK cascade |
| interleukin-12-mediated signaling pathway |
| cellular response to interleukin-12 |
| response to interleukin-12 |
| regulation of endothelial cell apoptotic process |
| regulation of vascular smooth muscle cell proliferation |
| negative regulation of muscle cell differentiation |
| cell aging |
| cardiac cell development |
| regulation of muscle cell apoptotic process |
| epithelial to mesenchymal transition |
| negative regulation of MAP kinase activity |
| positive regulation of NIK/NF-kappaB signaling |
| regulation of epithelial cell apoptotic process |
| regulation of JUN kinase activity |
| BMP signaling pathway |
| response to BMP |
| cellular response to BMP stimulus |
| regulation of NIK/NF-kappaB signaling |
| negative regulation of vasculature development |
| cardiocyte differentiation |
| regulation of smooth muscle cell proliferation |
| negative regulation of protein serine/threonine kinase activity |
| negative regulation of inflammatory response |
| positive regulation of inflammatory response |
| regulation of muscle cell differentiation |
| mesenchymal cell differentiation |
| negative regulation of MAPK cascade |
| cellular response to lipopolysaccharide |
| regulation of JNK cascade |
| cellular response to molecule of bacterial origin |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| negative regulation of defense response |
| cellular response to biotic stimulus |
| mesenchyme development |
| negative regulation of protein kinase activity |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| negative regulation of kinase activity |
| heart morphogenesis |
| negative regulation of cytokine production |
| negative regulation of transferase activity |
| aging |
| response to lipopolysaccharide |
| regulation of vasculature development |
| response to molecule of bacterial origin |
| regulation of inflammatory response |
| regulation of MAP kinase activity |
| negative regulation of response to external stimulus |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| positive regulation of defense response |
| cellular response to growth factor stimulus |
| negative regulation of intracellular signal transduction |
| regulation of protein serine/threonine kinase activity |
| cellular response to lipid |
| heart development |
| response to growth factor |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| positive regulation of response to external stimulus |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| response to bacterium |
| regulation of cytokine production |
| positive regulation of cell death |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of defense response |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| response to lipid |
| circulatory system development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| apoptotic process |
| negative regulation of developmental process |
| animal organ morphogenesis |
| regulation of transferase activity |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| negative regulation of gene expression |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| JQ1 0.8μM R08 exp435 | -2.12 |
| GSK-J4 1.5μM R08 exp441 | -2.04 |
| Aphidicolin 0.4μM R08 exp440 | -1.91 |
| Ammonium tetrathiomolybdate 10μM R08 exp448 | -1.75 |
| SGC2096 2.6μM R03 exp153 | 1.73 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12732
- Expression level (log2 read counts): 5.08
Expression Distribution
PDCD4 Expression in NALM6 Cells: 5.08
