PKD1L1
Gene Information
- Official Symbol: PKD1L1
- Official Name: polycystin 1 like 1, transient receptor potential channel interacting
- Aliases and Previous Symbols: N/A
- Entrez ID: 168507
- UniProt: Q8TDX9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. The encoded protein may play a role in the male reproductive system. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008].
- UniProt Summary: Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. {ECO:0000269|PubMed:24336289}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5416
- Expression level (log2 read counts): -1.23
PKD1L1 Expression in NALM6 Cells: -1.23
