PLEKHA8
Gene Information
- Official Symbol: PLEKHA8
- Official Name: pleckstrin homology domain containing A8
- Aliases and Previous Symbols: N/A
- Entrez ID: 84725
- UniProt: Q96JA3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. {ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:16103222, ECO:0000269|PubMed:17687330}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16615
- Expression level (log2 read counts): 5.36
PLEKHA8 Expression in NALM6 Cells: 5.36
