PNPLA6
Gene Information
- Official Symbol: PNPLA6
- Official Name: patatin like phospholipase domain containing 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 10908
- UniProt: Q8IY17
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
- UniProt Summary: N/A
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5906
- Expression level (log2 read counts): 5.73
PNPLA6 Expression in NALM6 Cells: 5.73
