PPP1R17
Gene Information
- Official Symbol: PPP1R17
- Official Name: protein phosphatase 1 regulatory subunit 17
- Aliases and Previous Symbols: N/A
- Entrez ID: 10842
- UniProt: O96001
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
- UniProt Summary: Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14955
- Expression level (log2 read counts): -5.01
PPP1R17 Expression in NALM6 Cells: -5.01
