PPP2R3A
Gene Information
- Official Symbol: PPP2R3A
- Official Name: protein phosphatase 2 regulatory subunit B
alpha * Aliases and Previous Symbols: N/A * Entrez ID: 5523 * UniProt: Q06190 * Interactions: BioGRID * PubMed articles: Open PubMed * OMIM: Open OMIM == Function Summary == * Entrez Summary: This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the Bfamily. The Bfamily has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]. - UniProt Summary: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17492
- Expression level (log2 read counts): 2.52
PPP2R3A Expression in NALM6 Cells: 2.52
