Pfam Domains GO Terms
| SPOC |
| RRM 1 |
| RNA N6-methyladenosine methyltransferase complex |
| dosage compensation by inactivation of X chromosome |
| dosage compensation |
| regulation of alternative mRNA splicing, via spliceosome |
| RNA methylation |
| regulation of mRNA splicing, via spliceosome |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| mRNA export from nucleus |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| regulation of RNA splicing |
| regulation of mRNA processing |
| protein export from nucleus |
| mRNA transport |
| nuclear export |
| RNA modification |
| nuclear envelope |
| RNA transport |
| nucleic acid transport |
| establishment of RNA localization |
| RNA localization |
| regulation of gene expression, epigenetic |
| nucleobase-containing compound transport |
| macromolecule methylation |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| nuclear transport |
| methylation |
| regulation of mRNA metabolic process |
| RNA splicing |
| nuclear speck |
| mRNA processing |
| mRNA metabolic process |
| viral process |
| symbiotic process |
| interspecies interaction between organisms |
| nucleolus |
| RNA processing |
| intracellular protein transport |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| protein transport |
| negative regulation of cellular biosynthetic process |
| intracellular transport |
| peptide transport |
| negative regulation of biosynthetic process |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| RNA metabolic process |
| negative regulation of gene expression |
| establishment of localization in cell |
| nitrogen compound transport |
| gene expression |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| 2-Methoxyestradiol 0.2μM R01 exp40 | -1.91 |
| Nicotinamide 2000μM R01 exp50 | -1.8 |
| Q15 2.7μM R02 exp79 | 1.71 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution