RC3H2
Gene Information
- Official Symbol: RC3H2
- Official Name: ring finger and CCCH-type domains 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 54542
- UniProt: Q9HBD1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| zf-CCCH |
GO Terms
| T follicular helper cell differentiation |
| negative regulation of T-helper 17 cell differentiation |
| regulation of miRNA metabolic process |
| negative regulation of T-helper 17 type immune response |
| negative regulation of T-helper cell differentiation |
| regulation of T-helper 17 cell differentiation |
| lymph node development |
| negative regulation of CD4-positive, alpha-beta T cell differentiation |
| regulation of T-helper 17 type immune response |
| RNA stem-loop binding |
| negative regulation of alpha-beta T cell differentiation |
| B cell homeostasis |
| CD4-positive, alpha-beta T cell differentiation involved in immune response |
| T-helper cell differentiation |
| alpha-beta T cell activation involved in immune response |
| alpha-beta T cell differentiation involved in immune response |
| negative regulation of CD4-positive, alpha-beta T cell activation |
| T cell differentiation involved in immune response |
| spleen development |
| T cell homeostasis |
| CD4-positive, alpha-beta T cell differentiation |
| regulation of T-helper cell differentiation |
| T cell proliferation |
| negative regulation of alpha-beta T cell activation |
| CD4-positive, alpha-beta T cell activation |
| negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| lung alveolus development |
| negative regulation of T cell differentiation |
| negative regulation of adaptive immune response |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| alpha-beta T cell differentiation |
| lymphocyte homeostasis |
| negative regulation of lymphocyte differentiation |
| regulation of CD4-positive, alpha-beta T cell activation |
| alpha-beta T cell activation |
| regulation of alpha-beta T cell differentiation |
| T cell activation involved in immune response |
| leukocyte homeostasis |
| double-stranded RNA binding |
| positive regulation of NIK/NF-kappaB signaling |
| multicellular organism growth |
| lymphocyte proliferation |
| P-body |
| mononuclear cell proliferation |
| post-embryonic development |
| regulation of alpha-beta T cell activation |
| leukocyte proliferation |
| negative regulation of leukocyte differentiation |
| regulation of NIK/NF-kappaB signaling |
| negative regulation of T cell activation |
| lymphocyte activation involved in immune response |
| negative regulation of immune effector process |
| negative regulation of leukocyte cell-cell adhesion |
| T cell differentiation |
| negative regulation of hemopoiesis |
| regulation of T cell differentiation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of lymphocyte activation |
| negative regulation of immune response |
| regulation of adaptive immune response |
| mRNA binding |
| regulation of lymphocyte differentiation |
| lung development |
| respiratory tube development |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| T cell receptor signaling pathway |
| limb development |
| appendage development |
| respiratory system development |
| negative regulation of cell activation |
| homeostasis of number of cells |
| T cell activation |
| lymphocyte differentiation |
| ubiquitin-protein transferase activity |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| antigen receptor-mediated signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| protein polyubiquitination |
| regulation of T cell activation |
| leukocyte differentiation |
| lymphocyte activation |
| developmental growth |
| growth |
| regulation of cell-cell adhesion |
| negative regulation of immune system process |
| immune response-activating cell surface receptor signaling pathway |
| regulation of hemopoiesis |
| regulation of immune effector process |
| immune response-regulating cell surface receptor signaling pathway |
| regulation of lymphocyte activation |
| posttranscriptional regulation of gene expression |
| cell population proliferation |
| hemopoiesis |
| immune response-activating signal transduction |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| cell surface |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| activation of immune response |
| regulation of cell activation |
| immune system development |
| regulation of cell adhesion |
| intracellular membrane-bounded organelle |
| protein ubiquitination |
| negative regulation of cell differentiation |
| protein modification by small protein conjugation |
| tube development |
| positive regulation of immune response |
| leukocyte activation |
| negative regulation of developmental process |
| protein modification by small protein conjugation or removal |
| positive regulation of intracellular signal transduction |
| cell activation |
| immune effector process |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| RNA binding |
| DNA binding |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| immune response |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Vemurafenib 6.6μM R02 exp89 | 1.75 |
| TRAIL 5ng/ml R00 exp35 | 1.94 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12468
- Expression level (log2 read counts): 6.61
Expression Distribution
RC3H2 Expression in NALM6 Cells: 6.61
