RDH10
Gene Information
- Official Symbol: RDH10
- Official Name: retinol dehydrogenase 10
- Aliases and Previous Symbols: N/A
- Entrez ID: 157506
- UniProt: Q8IZV5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol. {ECO:0000269|PubMed:12407145}.
Pfam Domains GO Terms
Pfam Domains
| KR |
| adh short |
GO Terms
| primary lung bud formation |
| positive regulation of retinoic acid biosynthetic process |
| positive regulation of isoprenoid metabolic process |
| regulation of retinoic acid biosynthetic process |
| regulation of isoprenoid metabolic process |
| positive regulation of vitamin metabolic process |
| morphogenesis of an epithelial bud |
| bud elongation involved in lung branching |
| retinoic acid biosynthetic process |
| diterpenoid biosynthetic process |
| embryonic viscerocranium morphogenesis |
| NADP-retinol dehydrogenase activity |
| regulation of vitamin metabolic process |
| retinal metabolic process |
| nose development |
| positive regulation of hormone metabolic process |
| terpenoid biosynthetic process |
| branch elongation of an epithelium |
| morphogenesis of an epithelial fold |
| retinol dehydrogenase activity |
| epithelial tube branching involved in lung morphogenesis |
| axis elongation |
| isoprenoid biosynthetic process |
| retinoic acid metabolic process |
| embryonic forelimb morphogenesis |
| animal organ formation |
| embryonic camera-type eye development |
| regulation of hormone metabolic process |
| retinol metabolic process |
| forelimb morphogenesis |
| lung morphogenesis |
| embryonic cranial skeleton morphogenesis |
| cellular aldehyde metabolic process |
| cranial skeletal system development |
| primary alcohol metabolic process |
| neural crest cell development |
| positive regulation of lipid biosynthetic process |
| lipid droplet |
| stem cell development |
| mesenchymal cell development |
| metanephros development |
| neural crest cell differentiation |
| embryonic skeletal system morphogenesis |
| retinoid metabolic process |
| diterpenoid metabolic process |
| developmental growth involved in morphogenesis |
| terpenoid metabolic process |
| cellular hormone metabolic process |
| embryonic limb morphogenesis |
| embryonic appendage morphogenesis |
| embryonic skeletal system development |
| branching morphogenesis of an epithelial tube |
| isoprenoid metabolic process |
| positive regulation of small molecule metabolic process |
| positive regulation of lipid metabolic process |
| morphogenesis of embryonic epithelium |
| appendage morphogenesis |
| limb morphogenesis |
| mesenchymal cell differentiation |
| stem cell differentiation |
| morphogenesis of a branching epithelium |
| morphogenesis of a branching structure |
| lung development |
| regulation of cellular ketone metabolic process |
| respiratory tube development |
| appendage development |
| limb development |
| monocarboxylic acid biosynthetic process |
| regulation of lipid biosynthetic process |
| respiratory system development |
| hormone metabolic process |
| gonad development |
| development of primary sexual characteristics |
| ear development |
| mesenchyme development |
| visual perception |
| sensory perception of light stimulus |
| skeletal system morphogenesis |
| sex differentiation |
| kidney development |
| renal system development |
| embryonic organ morphogenesis |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| epithelial tube morphogenesis |
| camera-type eye development |
| alcohol metabolic process |
| urogenital system development |
| eye development |
| visual system development |
| sensory system development |
| in utero embryonic development |
| developmental growth |
| growth |
| regulation of lipid metabolic process |
| reproductive structure development |
| regulation of small molecule metabolic process |
| reproductive system development |
| morphogenesis of an epithelium |
| embryonic organ development |
| organic hydroxy compound metabolic process |
| skeletal system development |
| monocarboxylic acid metabolic process |
| regulation of hormone levels |
| sensory organ development |
| tissue morphogenesis |
| embryonic morphogenesis |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| developmental process involved in reproduction |
| tube development |
| anatomical structure formation involved in morphogenesis |
| carboxylic acid metabolic process |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| animal organ morphogenesis |
| oxidation-reduction process |
| sensory perception |
| embryo development |
| oxoacid metabolic process |
| organic acid metabolic process |
| epithelium development |
| lipid metabolic process |
| nervous system process |
| reproductive process |
| reproduction |
| cell development |
| small molecule metabolic process |
| tissue development |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cidofovir 10μM R07 exp345 | 1.73 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 4091
- Expression level (log2 read counts): 4.52
Expression Distribution
RDH10 Expression in NALM6 Cells: 4.52
