RGS20
Gene Information
- Official Symbol: RGS20
- Official Name: regulator of G protein signaling 20
- Aliases and Previous Symbols: N/A
- Entrez ID: 8601
- UniProt: O76081
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). {ECO:0000250, ECO:0000269|PubMed:12379657}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15091
- Expression level (log2 read counts): -0.32
RGS20 Expression in NALM6 Cells: -0.32
