RHNO1
Gene Information
- Official Symbol: RHNO1
- Official Name: RAD9-HUS1-RAD1 interacting nuclear orphan 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 83695
- UniProt: Q9BSD3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation. {ECO:0000269|PubMed:21659603}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3092
- Expression level (log2 read counts): 4.46
RHNO1 Expression in NALM6 Cells: 4.46
