RPAP2

Entrez Summary: N/A
UniProt Summary: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580, ECO:0000269|PubMed:24997600}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.87
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.84
CyclicAMP 200μM R08 exp475	2.19

Global Fraction of Cell Lines Where Essential: 383/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	12/28
blood	17/28
bone	9/26
breast	16/33
central nervous system	22/56
cervix	1/4
colorectal	10/17
esophagus	7/13
fibroblast	0/1
gastric	10/16
kidney	6/21
liver	9/20
lung	46/75
lymphocyte	12/16
ovary	14/26
pancreas	14/24
peripheral nervous system	9/16
plasma cell	12/15
prostate	0/1
skin	13/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	15/22
urinary tract	11/29
uterus	3/5

Expression Distribution