S100A1
Gene Information
- Official Symbol: S100A1
- Official Name: S100 calcium binding protein A1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6271
- UniProt: P23297
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Probably acts as a Ca(2+) signal transducer (PubMed:22399290). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change (PubMed:23351007). This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity (PubMed:22399290). {ECO:0000269|PubMed:22399290, ECO:0000269|PubMed:23351007}.
Pfam Domains GO Terms
Pfam Domains
| efhand |
| S 100 |
GO Terms
| positive regulation of voltage-gated calcium channel activity |
| S100 protein binding |
| positive regulation of nitric-oxide synthase activity |
| positive regulation of monooxygenase activity |
| M band |
| regulation of voltage-gated calcium channel activity |
| positive regulation of calcium ion transmembrane transporter activity |
| positive regulation of sprouting angiogenesis |
| substantia nigra development |
| sarcoplasmic reticulum |
| regulation of nitric-oxide synthase activity |
| positive regulation of oxidoreductase activity |
| regulation of monooxygenase activity |
| calcium-dependent protein binding |
| neural nucleus development |
| positive regulation of cation channel activity |
| regulation of sprouting angiogenesis |
| positive regulation of calcium ion transmembrane transport |
| ATPase binding |
| midbrain development |
| regulation of calcium ion transmembrane transporter activity |
| regulation of oxidoreductase activity |
| toll-like receptor signaling pathway |
| positive regulation of ion transmembrane transporter activity |
| positive regulation of transporter activity |
| positive regulation of calcium ion transport |
| pattern recognition receptor signaling pathway |
| Z disc |
| positive regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transport |
| positive regulation of ion transmembrane transport |
| positive regulation of angiogenesis |
| regulation of cation channel activity |
| positive regulation of vasculature development |
| positive regulation of transmembrane transport |
| innate immune response-activating signal transduction |
| regulation of heart contraction |
| regulation of calcium ion transport |
| activation of innate immune response |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| positive regulation of ion transport |
| regulation of transporter activity |
| regulation of angiogenesis |
| regulation of blood circulation |
| regulation of vasculature development |
| neuron projection |
| regulation of cation transmembrane transport |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| regulation of metal ion transport |
| regulation of innate immune response |
| positive regulation of defense response |
| regulation of ion transmembrane transport |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| immune response-activating signal transduction |
| regulation of transmembrane transport |
| regulation of system process |
| immune response-regulating signaling pathway |
| protein-containing complex |
| positive regulation of response to external stimulus |
| activation of immune response |
| regulation of ion transport |
| calcium ion binding |
| brain development |
| regulation of defense response |
| regulation of multi-organism process |
| head development |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| protein homodimerization activity |
| central nervous system development |
| positive regulation of transport |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| regulation of response to external stimulus |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of immune system process |
| intracellular signal transduction |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of transport |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cincreasin 100μM R08 exp473 | -1.73 |
| PFI-3 10μM R03 exp144 | 1.76 |
| Dorsomorphin 5μM R07 exp357 | 2.1 |
| Thimerosal 0.85μM R08 exp529 | 2.26 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15672
- Expression level (log2 read counts): 1.43
Expression Distribution
S100A1 Expression in NALM6 Cells: 1.43
