SLC30A1
Gene Information
- Official Symbol: SLC30A1
- Official Name: solute carrier family 30 member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 7779
- UniProt: Q9Y6M5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be involved in zinc transport out of the cell.
Pfam Domains GO Terms
Pfam Domains
| Cation efflux |
GO Terms
| detoxification of cadmium ion |
| regulation of zinc ion transmembrane import |
| stress response to cadmium ion |
| regulation of zinc ion transmembrane transport |
| negative regulation of zinc ion transport |
| negative regulation of zinc ion transmembrane import |
| negative regulation of zinc ion transmembrane transport |
| regulation of zinc ion transport |
| cadmium ion transport |
| cadmium ion transmembrane transport |
| negative regulation of calcium ion import |
| calcium channel inhibitor activity |
| negative regulation of neurotransmitter secretion |
| detoxification of inorganic compound |
| stress response to metal ion |
| zinc ion transmembrane transporter activity |
| zinc ion transmembrane transport |
| negative regulation of neurotransmitter transport |
| zinc ion transport |
| cellular zinc ion homeostasis |
| zinc ion homeostasis |
| regulation of calcium ion import |
| T-tubule |
| calcium ion import |
| integral component of postsynaptic density membrane |
| negative regulation of calcium ion transport |
| negative regulation of synaptic transmission |
| response to cadmium ion |
| Schaffer collateral - CA1 synapse |
| negative regulation of cation transmembrane transport |
| negative regulation of ion transmembrane transport |
| regulation of neurotransmitter secretion |
| cellular transition metal ion homeostasis |
| negative regulation of transmembrane transport |
| transition metal ion transport |
| detoxification |
| transition metal ion homeostasis |
| regulation of neurotransmitter transport |
| negative regulation of ion transport |
| negative regulation of secretion by cell |
| negative regulation of secretion |
| nuclear membrane |
| regulation of calcium ion transport |
| calcium ion transport |
| divalent metal ion transport |
| divalent inorganic cation transport |
| regulation of cation transmembrane transport |
| regulation of neurotransmitter levels |
| response to metal ion |
| in utero embryonic development |
| regulation of metal ion transport |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| response to toxic substance |
| response to inorganic substance |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| chordate embryonic development |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| embryo development ending in birth or egg hatching |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of secretion |
| cation transport |
| cellular homeostasis |
| regulation of cellular localization |
| ion transmembrane transport |
| embryo development |
| Golgi apparatus |
| endoplasmic reticulum |
| chemical homeostasis |
| transmembrane transport |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| homeostatic process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Disulfiram 4.3μM R06 exp281 | -4.1 |
| ABT-702 5μM plus CoCl2 18μM R07 exp320 | -3.95 |
| CoCl2 18μM R07 exp346 | -3.31 |
| GSK-J4 1μM R07 exp362 | -2.89 |
| BI-6727 0.04μM R03 exp98 | -2.58 |
| Nocodazole 0.1μM R03 exp94 | -2.24 |
| GSK-J4 1-1.25μM to day4 R07 exp363 | -1.99 |
| SB743921 0.001μM R05 exp244 | -1.71 |
| TIC10 10μM R08 exp532 | 1.72 |
| Tubacin 1.6μM R07 exp416 | 1.94 |
| HMS-I1 1μM R01 exp46 | 2.08 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11099
- Expression level (log2 read counts): 5.09
Expression Distribution
SLC30A1 Expression in NALM6 Cells: 5.09
