SMAD5

Gene Information

Official Symbol: SMAD5
Official Name: SMAD family member 5
Aliases and Previous Symbols: N/A
Entrez ID: 4090
UniProt: Q99717
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
UniProt Summary: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).

Pfam Domains GO Terms

Pfam Domains

IRF-3

MH1

MH2

GO Terms

Mullerian duct regression

osteoblast fate commitment

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

SMAD protein complex

DEAD/H-box RNA helicase binding

anatomical structure regression

positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

SMAD protein signal transduction

positive regulation of osteoblast differentiation

embryonic pattern specification

cardiac muscle contraction

erythrocyte differentiation

positive regulation of ossification

ureteric bud development

mesonephric tubule development

mesonephric epithelium development

heart contraction

erythrocyte homeostasis

BMP signaling pathway

mesonephros development

heart process

transforming growth factor beta receptor signaling pathway

cellular response to BMP stimulus

response to BMP

myeloid cell homeostasis

striated muscle contraction

regulation of osteoblast differentiation

osteoblast differentiation

kidney epithelium development

cellular response to transforming growth factor beta stimulus

male sex differentiation

response to transforming growth factor beta

cartilage development

regulation of ossification

transmembrane receptor protein serine/threonine kinase signaling pathway

homeostasis of number of cells

bone development

transcription factor complex

myeloid cell differentiation

connective tissue development

cell fate commitment

muscle contraction

germ cell development

ossification

sex differentiation

kidney development

renal system development

ubiquitin protein ligase binding

muscle system process

urogenital system development

cellular process involved in reproduction in multicellular organism

blood circulation

circulatory system process

pattern specification process

skeletal system development

cellular response to growth factor stimulus

RNA polymerase II proximal promoter sequence-specific DNA binding

response to growth factor

cellular response to organic cyclic compound

hemopoiesis

protein-containing complex

hematopoietic or lymphoid organ development

immune system development

developmental process involved in reproduction

gamete generation

enzyme linked receptor protein signaling pathway

multicellular organismal reproductive process

sexual reproduction

multicellular organism reproduction

tube development

negative regulation of transcription by RNA polymerase II

response to organic cyclic compound

positive regulation of cell differentiation

protein phosphorylation

embryo development

multi-organism reproductive process

epithelium development

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

cellular response to endogenous stimulus

negative regulation of nucleic acid-templated transcription

negative regulation of RNA biosynthetic process

phosphorylation

negative regulation of RNA metabolic process

positive regulation of developmental process

negative regulation of cellular macromolecule biosynthetic process

reproductive process

reproduction

negative regulation of nucleobase-containing compound metabolic process

negative regulation of macromolecule biosynthetic process

response to endogenous stimulus

negative regulation of cellular biosynthetic process

positive regulation of transcription, DNA-templated

negative regulation of biosynthetic process

DNA-binding transcription factor activity, RNA polymerase II-specific

positive regulation of nucleic acid-templated transcription

positive regulation of RNA biosynthetic process

homeostatic process

cell development

negative regulation of gene expression

positive regulation of RNA metabolic process

positive regulation of multicellular organismal process

tissue development

regulation of cell differentiation

positive regulation of nucleobase-containing compound metabolic process

positive regulation of macromolecule biosynthetic process

system process

positive regulation of cellular biosynthetic process

positive regulation of gene expression

positive regulation of biosynthetic process

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

Screen	Score
Milciclib 2μM R08 exp502	-2.14
42°C R08 exp539	-1.78
CVT-10216 0.1μM R06 exp278	1.76
Golgicide-A 4μM R03 exp122	1.79

Most Correlated Genes in Chemogenomics

No correlation found to any other genes in chemogenomics.

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: N/A

Tissue	Fraction Of Cell Lines Where Essential

Essentiality in NALM6

Essentiality Rank: 15708
Expression level (log2 read counts): 6.23

Expression Distribution