SNRPC
Gene Information
- Official Symbol: SNRPC
- Official Name: small nuclear ribonucleoprotein polypeptide C
- Aliases and Previous Symbols: N/A
- Entrez ID: 6631
- UniProt: P09234
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {ECO:0000255|HAMAP- Rule:MF_03153, ECO:0000269|PubMed:1826349, ECO:0000269|PubMed:2136774, ECO:0000269|PubMed:8798632}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1412
- Expression level (log2 read counts): 6.42
SNRPC Expression in NALM6 Cells: 6.42
