SPRED2
Gene Information
- Official Symbol: SPRED2
- Official Name: sprouty related EVH1 domain containing 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 200734
- UniProt: Q7Z698
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. {ECO:0000269|PubMed:15683364}.
Pfam Domains GO Terms
Pfam Domains
| Sprouty |
| WH1 |
GO Terms
| stem cell factor receptor binding |
| protein serine/threonine kinase inhibitor activity |
| positive regulation of DNA damage response, signal transduction by p53 class mediator |
| negative regulation of peptidyl-threonine phosphorylation |
| positive regulation of signal transduction by p53 class mediator |
| inactivation of MAPK activity |
| regulation of DNA damage response, signal transduction by p53 class mediator |
| transport vesicle membrane |
| regulation of protein deacetylation |
| regulation of peptidyl-threonine phosphorylation |
| negative regulation of MAP kinase activity |
| fibroblast growth factor receptor signaling pathway |
| positive regulation of response to DNA damage stimulus |
| cellular response to fibroblast growth factor stimulus |
| response to fibroblast growth factor |
| negative regulation of protein serine/threonine kinase activity |
| negative regulation of MAPK cascade |
| regulation of signal transduction by p53 class mediator |
| regulation of response to DNA damage stimulus |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| negative regulation of transferase activity |
| regulation of MAP kinase activity |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| protein kinase binding |
| cellular response to growth factor stimulus |
| negative regulation of intracellular signal transduction |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of protein serine/threonine kinase activity |
| response to growth factor |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| enzyme linked receptor protein signaling pathway |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of kinase activity |
| regulation of transferase activity |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-D1870 3.15μM R02 exp66 | 1.73 |
| LLY-284 2.6μM R06 exp291 | 1.78 |
| Dynasore 10μM R04 exp180 | 1.89 |
| GSK626616 14μM R08 exp485 | 1.94 |
| Wortmannin 5μM R00 exp38 | 2.24 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7801
- Expression level (log2 read counts): 5.05
Expression Distribution
SPRED2 Expression in NALM6 Cells: 5.05
