STX5

Entrez Summary: This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q08851}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
AICAR 240μM R03 exp116	1.72
UM0125461 0.74μM R02 exp84	2.18

Global Fraction of Cell Lines Where Essential: 338/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	15/28
blood	12/28
bone	15/26
breast	19/33
central nervous system	25/56
cervix	3/4
colorectal	9/17
esophagus	5/13
fibroblast	1/1
gastric	9/16
kidney	12/21
liver	10/20
lung	32/75
lymphocyte	7/16
ovary	14/26
pancreas	8/24
peripheral nervous system	8/16
plasma cell	8/15
prostate	1/1
skin	6/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	9/22
urinary tract	10/29
uterus	2/5

Expression Distribution