THOC7
Gene Information
- Official Symbol: THOC7
- Official Name: THO complex 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 80145
- UniProt: Q6I9Y2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:23222130}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1416
- Expression level (log2 read counts): 4.8
THOC7 Expression in NALM6 Cells: 4.8
