Pfam Domains GO Terms
| TLD |
| positive regulation of protein localization to lysosome |
| regulation of protein localization to lysosome |
| negative regulation of oxidative stress-induced neuron death |
| regulation of oxidative stress-induced neuron death |
| TOR signaling |
| negative regulation of cellular response to oxidative stress |
| negative regulation of oxidative stress-induced cell death |
| negative regulation of response to oxidative stress |
| regulation of oxidative stress-induced cell death |
| regulation of cellular response to oxidative stress |
| regulation of response to oxidative stress |
| response to amino acid |
| negative regulation of neuron death |
| response to insulin |
| lysosomal membrane |
| regulation of neuron death |
| positive regulation of cellular protein localization |
| response to acid chemical |
| response to peptide hormone |
| response to peptide |
| response to nutrient levels |
| response to extracellular stimulus |
| regulation of cellular protein localization |
| regulation of cellular response to stress |
| regulation of cell migration |
| response to hormone |
| regulation of cell motility |
| regulation of cellular localization |
| regulation of locomotion |
| negative regulation of cell death |
| regulation of cellular component movement |
| response to organonitrogen compound |
| regulation of protein localization |
| response to nitrogen compound |
| response to endogenous stimulus |
| regulation of response to stress |
| response to oxygen-containing compound |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of cell death |
| intracellular signal transduction |
| membrane |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| Adefovir 20μM R07 exp332 | -1.78 |
| Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307 | -1.75 |
| Nutlin-3A 1.6μM R06 exp294 | 1.85 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution