TMEM135

Entrez Summary: N/A
UniProt Summary: Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization. {ECO:0000250|UniProtKB:Q5U4F4, ECO:0000250|UniProtKB:Q9CYV5}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CHIR-124 0.04μM R06 exp272	-2.53
Epigallocatechin gallate 20μM R05 exp230	1.75
Cabazitaxel 0.001μM R05 exp223	1.83
Tanespimycin 14μM R08 exp527	1.85
Deguelin 0.15μM R05 exp209	1.92
Ibrutinib 1μM R07 exp372	1.92
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.94
Etoposide 0.1μM R05 exp198	2
UM0011500 10μM R05 exp246	2.03
Hypoxia 5%O2 R04 exp191	2.32

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution