TMEM231
Gene Information
- Official Symbol: TMEM231
- Official Name: transmembrane protein 231
- Aliases and Previous Symbols: N/A
- Entrez ID: 79583
- UniProt: Q9H6L2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a transmembrane protein, which is a component of the B9 complex involved in the formation of the diffusion barrier between the cilia and plasma membrane. Mutations in this gene cause Joubert syndrome (JBTS). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013].
- UniProt Summary: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11475
- Expression level (log2 read counts): 3.43
TMEM231 Expression in NALM6 Cells: 3.43
