TMEM258

Entrez Summary: N/A
UniProt Summary: Acts as component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for full OST catalytic activity in N-glycosylation (PubMed:26472760, PubMed:27974209). Involved in endoplasmic reticulum (ER) homeostasis in the colonic epithelium (By similarity). {ECO:0000250|UniProtKB:P61166, ECO:0000269|PubMed:26472760, ECO:0000269|PubMed:27974209}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 288/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	12/28
blood	9/28
bone	7/26
breast	4/33
central nervous system	25/56
cervix	2/4
colorectal	6/17
esophagus	3/13
fibroblast	0/1
gastric	7/16
kidney	14/21
liver	12/20
lung	32/75
lymphocyte	6/16
ovary	14/26
pancreas	11/24
peripheral nervous system	5/16
plasma cell	4/15
prostate	1/1
skin	10/24
soft tissue	4/9
thyroid	1/2
upper aerodigestive	9/22
urinary tract	9/29
uterus	4/5

Expression Distribution